Libro blanco de las ACES Pediátricas 2024

Libro Blanco de las ACES Pediátricas 2024 698 ❚ 1. Know that passive smoking may be a potent stimulus for bronchoconstriction in children with pre-existing reactive airways disease 3. Interventions a. Preventions 1. Know that smoking prevention would be the most effective public health measure possible in terms of reducing mortality in the United States b. Smoking cessation 1. Know that effective smoking cessation must take into account the fact that for many people smoking is both a habit and an addiction C. Neonatal infections 1. Know that treatment of pregnant women colonized with Chlamydia trachomatis may prevent disease in the infant 2. Know that routine eye prophylaxis in a newborn infant colonized with Chlamydia trachomatis does not prevent the onset of pneumonia 5. Lung Growth and Development A. Fetal 1. Structure a. Embryonic stage 1. Know that the lung arises as an outpouching of the primitive gut 2. Know the characteristics of the embryonic stage of lung development 3. Know that the major bronchial divisions are formed by 16 weeks of gestation 4. Know that transcription factors direct branching morphogenesis 5. Know that transcription factors are involved in cell commitment and differentiation 6. Know the postconceptional time of the embryonic stage (i.e., 3 to 6 weeks postconception) 7. Know that normal airway branching involves signaling between endoderm and mesoderm and that the mesoderm directs the branching pattern b. Pseudoglandular stage 1. Know the histologic characteristics of the pseudoglandular stage of lung development 2. Know the postconceptional time of the pseudoglandular stage (i.e., 6 to 16 weeks postconception) 3. Know that most gross congenital abnormalities in lung development (bronchopulmonary sequestration, cystic adenomatoid malformation, and congenital diaphragmatic hernia) arise during the pseudoglandular phase of development c. Canalicular stage 1. Know the histologic characteristics of the canalicular stage of lung development 2. Know the postconceptional time of the canalicular stage (i.e., 16 to 26 weeks postconception) d. Saccular stage 1. Know the histologic characteristics of the saccular stage of lung development 2. Know the postconceptional time of the saccular stage (i.e., 26 to 36 weeks postconception) e. Alveolar stage