Libro blanco de las ACES Pediátricas 2024

Endocrinología Pediátrica. Anexos ❚ 175 39 J. PARATHYROID GLANDS, METABOLIC BONE AND MINERAL DISORDERS 1 Physiology of Calcium, Phosphate, Vitamin D, Parathyroid hormone (PTH) and FGF23 B 2 Bone biology • Skeletal development, osteoblast, osteoclast and osteocyte function • Bone modelling and remodelling • Histology of bone in the context of mineral, cartilage & collagen formation & function B 3 Radiology: findings, interpretation, differential diagnosis for specific disorders • Rickets • Osteogenesis imperfecta • Basics of skeletal dysplasia C 4 Bone densitometry measurement techniques, size correction in paediatrics, interpretation, use in management of altered bone mass conditions D 5 Metabolic bone disease of prematurity: pathophysiology, investigations, management and ongoing monitoring C 6 Hypocalcaemia • Approach to management and including management of specific conditions • Transient neonatal hypocalcemia • Genetic disorders of calcium-sensing receptor (CaSR) and parathyroid gland development • Hypoparathyroidism due to metabolic & syndromic causes o DiGeorge or 22q11.2 deletion syndrome o As part of APS1 • Pseudohypoparathyroidism and its different forms 25 • Acquired hypoparathyroidism • Magnesium deficiency C C D D C D C 7 Hypercalcaemia • Approach to management and including management of specific conditions • Abnormal vitamin D metabolism • Disorders with suppressed PTH secretion, e.g. Williams syndrome, subcutaneous fat necrosis, hypercalcaemia of infancy • Disorders of calcium-sensing receptor associated with hypercalcaemia • Disorders of parathyroid glands/PTH oversecretion C D C C D