LIBRO + ANEXOS ENDOCRINOLOGÍA PEDIÁTRICA

Endocrinología Pediátrica. Anexos ❚ 69 45 N. DISORDERS OF OVARIES AND FEMALE REPRODUCTIVE TRACT 1 Ovarian structure and function • Granulosa and theca cells, follicular development, corpus luteum, germ cells reserve through life • Hormones secreted and changes across fetal life, infancy, childhood and puberty • Regulation by LH and FSH, role of receptors, negative and positive feedback in the hypothalamic-pituitary-ovarian axis B 2 Ovarian failure: 42 • Approach to management and including management of specific conditions • Primary vs secondary, hypogonadotrophic vs hypergonadotrophic • Aetiology: congenital and acquired, sporadic or familial, isolated or syndromic • Fertility and psychosexual outcome • Turner syndrome 4 C 3 Ovarian hyperandrogenism: • primary vs secondary • Polycystic Ovary Syndrome (PCOS) 43 • Androgen secreting ovarian tumour C D 4 Ovarian cysts: follicular, other cysts C 5 Ovarian tumours • Germ cell (germinoma/dysgerminoma, teratoma) • Mesenchymal (granulosa cell) • Adrenal rest tumour associated with congenital adrenal hyperplasia D C 6 Menstrual problems: • Amenorrhoea: primary and secondary • Disorders of menstrual frequency, duration and flow • Dysmenorrhoea • Premenstrual syndrome C 7 Non-menstrual vaginal bleeding: • Pathological vs sexual abuse vs factitious • Approach to investigating C 8 Oestrogen and oestrogen-progesterone hormone replacement 44 • Preparations and routes of administration • Indications, doses and duration of treatment o constitutional delay in puberty o pubertal hormone replacement C