LIBRO + ANEXOS NEUMOLOGÍA PEDIÁTRICA

Libro Blanco de las ACES Pediátricas 2024 122 ❚ g. Complications 1. Know the association between bronchiolitis in infancy and subsequent lower respiratory tract symptoms 2. Know there is increased risk of aspiration in otherwise healthy infants with respiratory syncytial virus bronchiolitis 5. Prevention and therapeutic approach a. Prevention 1. Know how to reduce nosocomial transmission of respiratory syncytial virus b. Therapeutic approach 1. Know the indications for oxygen therapy in infants with bronchiolitis 2. Know the effects of adrenergic agonists on patients with viral bronchiolitis 3. Know that antibiotic and corticosteroid therapies are rarely indicated for infants with uncomplicated viral bronchiolitis 4. Know the treatment of pulmonary graft-versus-host disease in a patient who has received a bone marrow transplant c. Side effects of therapy 6. Prognosis a. Natural history b. Prognosis with therapy E. Cystic fibrosis 1. Epidemiology 2. Etiology/genetics a. Given an incidence figure for cystic fibrosis in the population, be able to calculate the probable carrier rate b. Given the scenario of two parents who have a child with cystic fibrosis, be able to calculate the odds that future children will have cystic fibrosis, be heterozygote carriers, or be homozygous normal c. Be able to calculate the odds that siblings, aunts, and uncles of patients with cystic fibrosis will have a child with cystic fibrosis d. Know the most common gene mutation that causes cystic fibrosis in North America e. Recognize the benefits and limitations of newborn screening for cystic fibrosis f. Know the commonly used methods for cystic fibrosis newborn screening (IRT and DNA testing) g. Be able to interpret the results of newborn screening for cystic fibrosis and understand the need for appropriate confirmatory testing 3. Pathophysiology a. Pathology 1. Know the major pathologic features of the lungs and pancreas in patients with cystic fibrosis 2. Know the evolution of airway damage in the lungs of patients with cystic fibrosis b. Path mechanisms and consequences 1. Know that chloride permeability of epithelial cells is abnormal in cystic fibrosis 2. Know the putative relationship between the chloride defect in cystic fibrosis and abnormalities in the respiratory tract, pancreatic ducts, and sweat glands