LIBRO + ANEXOS NEUMOLOGÍA PEDIÁTRICA

Libro Blanco de las ACES Pediátricas 2024 180 ❚ c. Pathophysiology 1. Pathology 2. Path mechanisms and consequences a. Know that the pathogenesis of hypersensitivity pneumonitis involves IgG- mediated and lymphocyte-mediated mechanisms but not IgE-mediated mechanisms d. Diagnosis and clinical manifestations 1. History a. Know that hypersensitivity pneumonitis may manifest itself as an acute, subacute, or chronic illness b. Recognize the historical features typical of hypersensitivity pneumonitis 2. Physical examination a. Know that inspiratory crackles, not wheezes, are characteristic of acute hypersensitivity pneumonitis 3. Imaging a. Recognize the radiographic manifestations of hypersensitivity pneumonitis 4. Pulmonary function tests 5. Other investigations a. Know that patients with hypersensitivity pneumonitis will have precipitating antibodies to the offending antigen but that the presence of such antibodies alone is not diagnostic b. Recognize findings typical of hypersensitivity pneumonitis on bronchoalveolar lavage 6. Diagnostic criteria 7. Complications a. Know that hypersensitivity pneumonitis may progress to end-stage pulmonary fibrosis and respiratory failure e. Prevention and therapeutic approach 1. Prevention 2. Therapeutic approach 3. Side effects of therapy f. Prognosis 1. Natural history a. Know that the condition of most patients with hypersensitivity pneumonitis will improve after they are removed from the source of antigen 2. Prognosis with therapy 7. Wegener granulomatosis a. Know which therapy is most likely to induce remission of Wegener granulomatosis 8. Neuromuscular disorders a. Understand that patients with Duchenne muscular dystrophy usually have normal ventilatory drive b. Understand how chest wall compliance is affected by chronic neuromuscular disorders c. Recognize the inheritance pattern and genetic mechanism underlying Duchenne muscular dystrophy (X-linked recessive loss of function)